Eficacia terapéutica comparativa de dosis de sulfato de Vincristina en perros mestizos con tumor venéreo transmisible
DOI:
https://doi.org/10.56124/allpa.v8i16.0125Palabras clave:
Tumor venéreo transmisible, sulfato de Vincristina, quimioterapia veterinaria, citologíaResumen
El tumor venéreo transmisible (TVT) canino es una neoplasia contagiosa que representa un desafío terapéutico y epidemiológico a nivel global. Este estudio evaluó la eficacia del sulfato de Vincristina administrado intravenosamente bajo dos protocolos semanales: un esquema ajustado (0.5–0.7 mg/m²) y otro fijo (0.75 mg/m²) durante seis semanas consecutivas. Se reportan dos casos clínicos con afectación genital y cutánea metastásica, respectivamente. Ambos protocolos lograron más del 90% de reducción tumoral, con una respuesta más rápida en el esquema ajustado (86.7% a la semana cinco frente a 75% en el fijo). Los análisis citológicos mostraron reducción progresiva de células neoplásicas, presencia de infiltrado inflamatorio y signos claros de degeneración celular, sin evidencias de recurrencia tumoral. No se observaron efectos adversos hematológicos ni sistémicos relevantes. Los resultados confirman la alta eficacia y seguridad del sulfato de Vincristina en TVT y sugieren que la individualización del esquema puede acelerar la respuesta sin comprometer su efectividad terapéutica.
Palabras clave: Tumor venéreo transmisible, sulfato de Vincristina, quimioterapia veterinaria, citología.
Abstract
Canine transmissible venereal tumor (TVT) is a contagious neoplasm that poses therapeutic and epidemiological challenges worldwide. This study evaluated the efficacy of intravenous vincristine sulfate administered under two weekly protocols: an adjusted regimen (0.5–0.7 mg/m²) and a fixed dose (0.75 mg/m²) over six consecutive weeks. Two clinical cases with genital and metastatic cutaneous involvement, respectively, are reported. Both protocols achieved over 90% tumor reduction, with a faster response observed in the adjusted protocol (86.7% reduction at week five versus 75% in the fixed-dose group). Cytological analyses demonstrated progressive decrease in neoplastic cell populations, presence of inflammatory infiltrates, and clear signs of cellular degeneration, with no evidence of tumor recurrence. No significant hematological or systemic adverse effects were observed. The results confirm the high efficacy and safety of vincristine sulfate in TVT treatment and suggest that individualized dosing protocols may accelerate therapeutic response without compromising treatment effectiveness.
Keywords: Transmissible venereal tumor, vincristine sulfate, veterinary chemotherapy, cytology.
Fecha de recepción: 09 de abril de 2025; Fecha de aceptación: 18 de junio de 2025; Fecha de publicación: 09 de julio del 2025.
Descargas
Citas
Antonov, A. (2015). Successful treatment of canine transmissible venereal tumor using vincristine sulfate. Advances in Research, 5(5), 1–5. https://doi.org/10.9734/AIR/2015/20017
Abdelnaby, E. A., Abouelela, Y. S., & Yasin, N. A. E. (2021). Evaluation of penile blood flow in dogs with TVT before and after chemotherapeutic treatment with special reference to its angioarchitecture. Advances in Animal and Veterinary Sciences, 9(8), 1159–1168. https://doi.org/10.17582/journal.aavs/2021/9.8.1159.1168
Berndt, T. R., Rosa, A. C., & Kataoka, A. (2016). Tumor venéreo transmissível – Revisão de literatura. Sci. Elec. Arch, 9(5), 170–176. https://scholar.archive.org/work/6vcoyys67rcmfjvi3ej4rccztq/access/wayback/http://www.seasinop.com.br/revista/index.php?journal=SEA&page=article&op=download&path%5B%5D=246&path%5B%5D=pdf
Eze, C. A., Kene, R. O. C., & Anyanwu, H. C. (2014). Comparative efficacy of surgery, vincristine sulphate and combined therapy of levamisole and Bacille Calmette Guerin vaccine in the treatment of transmissible venereal tumour-infected dogs. Comparative Clinical Pathology, 23(5), 1263–1267. https://doi.org/10.1007/s00580-013-1773-x
Hantrakul, S., Klangkaew, N., Kunakornsawat, S., Tansatit, T., Poapolathep, A., Kumagai, S., & Poapolathep, S. (2014). Clinical pharmacokinetics and effects of vincristine sulfate in dogs with transmissible venereal tumor (TVT). Journal of Veterinary Medical Science, 76(12), 1549–1553. https://doi.org/10.1292/jvms.14-0180
Hayes, A. M., Schiavo, L., Constantino-Casas, F., Desmas, I., Dobson, J., Draper, A., Elliot, J., Genain, M. A., Wang, J., & Murchison, E. P. (2023). Transmission of canine transmissible venereal tumour between two dogs in the UK. Journal of Small Animal Practice, 64(9), 590–594. https://doi.org/10.1111/jsap.13607
Hiblu, M. A., Khabuli, N. M., & Gaja, A. O. (2019). Canine transmissible venereal tumour: First report of clinical cases from Tripoli, Libya. Open Veterinary Journal, 9(2), 103–105. https://doi.org/10.4314/ovj.v9i2.1
Kumar, K., Jha, A. K., Ray, K., Gautam, A. K., & Singh, D. (2021). Diagnosis of TVT with cell cytology and efficacy of treatment with vincristine sulfate in non-descriptive Indian canine breeds. Indian Journal of Animal Research, 55, 1352–1355. https://doi.org/10.18805/IJAR.B-4175
Leil, A. Z. A., El-Hallawany, H. A., & Abd El-Rahman, H. M. A. (2022). Clinical response of dogs affected with transmissible venereal tumor (TVT) to the chemotherapeutic regime with regard to cytomorphology and histopathology. Journal of Applied Veterinary Sciences, 7(2), 58–65. https://doi.org/10.21608/javs.2022.123900.1132
Ojeda, J., Alfaro, A., Moroni, M., Camacho, V., Martínez, J., & Noro, M. (2016). Tumor venéreo transmisible diseminado sobre piel, párpados y pene en un perro. Reporte de caso. Austral Journal of Veterinary Sciences, 48(1), 69–73. Recuperado de http://www.redalyc.org/articulo.oa?id=501752373015
Peña, G. I., Vidal, F. F., del Toro, R. A., & Hernández, R. A. (2017). Empleo del sulfato de vincristina, vía subcutánea, para el control del tumor venéreo transmisible canino: estudio retrospectivo de siete casos en Camagüey, Cuba. Revista de Investigación Veterinaria del Perú, 28(3), 750–756. https://doi.org/10.15381/rivep.v28i3.13363
Paranzini, C. S., Sant’anna, M. C., di Santis, G. W., & Martins, M. I. M. (2015). Prevalence of different cytomorphological types of transmissible venereal tumours and the association with prognosis in dogs treated with vincristine sulphate. Retrospective study. Semina Ciências Agrárias, 36(6), 3795–3800. https://doi.org/10.5433/1679-0359.2015v36n6p3795
Santana, D. A., García Cuellar, A. R., Maltes Sánchez, J. M., Ortiz Fajardo, D. A., & Valencia Hernández, A. F. (2016). Efecto del sulfato de vincristina sobre las células hematológicas en un paciente con tumor venéreo transmisible (TVT). Revista Electrónica Veterinaria (REDVET), 17(4), 1–13. Recuperado de https://www.redalyc.org/pdf/636/63646041006.pdf
Setthawongsin, C., Teewasutrakul, P., Tangkawattana, S., Techangamsuwan, S., & Rungsipipat, A. (2019). Conventional-vincristine sulfate vs. modified protocol of vincristine sulfate and L-asparaginase in canine transmissible venereal tumor. Frontiers in Veterinary Science, 6, 300. https://doi.org/10.3389/fvets.2019.00300
Ugochukwu, I. C. I., Agina, O. A., Omeke, J. N., Aneke, C. I., Adamu, L. F., Ajayi, O. L., Ibrahim, N. D. G., Njoku, C. I., Sackey, A. K. B., & Ihedioha, J. I. (2020). An appraisal of Canine Transmissible Venereal Tumour with emphasis on molecular biology and pathology. Thai Journal of Veterinary Medicine, 50(1), 1–12. Recuperado de https://he01.tci-thaijo.org/index.php/tjvm/article/view/243251
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2025 Revista de Ciencias Agropecuarias ALLPA. ISSN: 2600-5883.
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
.jpg)
